Mass Spec 2023

Quantitative Proteomics for Understanding Histone Mutations in Human Disease (45 minutes)

Q&A (15 minutes)




Session Speaker: Benjamin Garcia, Washington University in St. Louis

Session Speakers:




Importance of Disulfide Bond re-arrangement in vitro and in vivo: Evidence and Approaches to Address It
Franta Hubálek, Novo Nordisk A/S




Development of a Rapid and Automated, Compliance Ready Workflow for Full Sequence Coverage of RNAi Therapeutics
Jennifer Nguyen, Alnylam Pharmaceuticals




Elucidation, Characterization and Monitoring of a Unique Tyrosine Sulfation Post-Translational Modification During Bispecific Antibody Process Development and Scaleup
David Mahon, Bristol-Myers Squibb Company

Technical Seminar Lunch & Learn Sessions are for Mass Spec attendees only. HOS attendees and those not wishing to attend should grab their lunch and proceed to the Explore Room (Floor 2).

Session Speakers:




High-Order Structure Characterization of Membrane Proteins Using Benzoyl Fluoride Footprinting
Mengqi Chai, Washington University in St. Louis  

  

In Depth Characterization of Biologics Through a Combination of Mass Spectrometry and Molecular Modeling
Naresh Chennamsetty, Bristol-Myers Squibb Company




Protein Footprinting for Structural Biology in Complex Model Systems
Lisa Jones, University of California San Diego    




Complementary Backbone and Side Chain Analysis of Drug – Protein Interactions Combining Hydrogen/Deuterium Exchange and Protein Oxidative Mass Spectrometry
Yan Sun, Albert Einstein College of Medicine    

Session Speaker:




Mass Spectrometry Enables More Definitive Process & Product Development Towards Well-Characterized Biotherapeutics: A Personal Account
Jason Rouse, Pfizer, Inc.

Session Speakers:




Applications of Mass Spectrometry in CRISPR based Cell Therapy and Gene Editing Therapy
Bo Yan, Beam Therapeutics    




LC-MS/MS as a Potency Assay for mRNA Vaccines
Aline Dörrbaum, BioNTech SE    




Proteomic Approaches for Characterization of Live Biotherapeutic Escherichia coli Nissle Products from Fermentation to Therapeutic Activity
Steven Bruckbauer, Synlogic Operating Company

Mass Spec attendees should grab their lunch and beverages and return to the general session room if they plan on attending the vendor showcase. 

*The vendor showcases are not part of the HOS Symposium.

HOS attendees should grab their lunch and proceed to the meal room to eat. 

Featured Panelists:




Wayne Hicks, CBER, FDA  

Frances Namuswe, CDER, FDA  

Sarah Rogstad, CDER, FDA

Session Speaker:




Perspective on MAM
Tura Camilli, Genentech, a Member of the Roche Group

Session Speakers:




Oligonucleotide Mapping via LC-UV-MS/MS to Enable Comprehensive Primary Structure Characterization of mRNA
Andrew Dawdy, Pfizer, Inc.    




High-Throughput Characterization of Antibodies via Automated Microdroplet Reactions
Harsha Gunawardena, Janssen Research & Development, LLC

    

Exposing the Molecular Heterogeneity of Glycosylated Therapeutics
Rafael Melani, Thermo Fisher Scientific    

Session Speakers:




Assay Replacement Strategies using MAM
Adam Evans, Janssen Research and Development, LLC    




Intact-level Multi-Attribute Monitoring of Complex Biologics Using Imaged Capillary Isoelectric Focusing with UV/MS (icIEF-UV/MS)
Anita Liu, Merck & Co., Inc.    




Comprehensive Characterization of Adeno Associated Virus Therapeutics using Mass Spectrometry Methods
Shannon Raab, Eli Lilly and Company