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How can High-Resolution Ion Mobility Mass Spectrometry (HRIM-MS) address the challenges of large molecule characterization? This seminar will discuss the benefits of HRIM-MS in enhancing structural characterization of large molecule therapeutics, while increasing throughput and reducing reliance on LC-based methods. Specific focus will be on how HRIM-MS provides more complete information on coeluting structural isomers, as well as and on emerging workflows.