Mass Photometry – An Analytical Technology for Biomolecular Characterization

Jan 23, 2023 2:25pm ‐ Jan 23, 2023 2:50pm

Mass photometry is a single-particle analytical technology that measures the masses of biomolecules in their native states, in solution. The TwoMP and SamuxMP mass photometers are easy-to-use instruments that can measure masses of biomolecules between 30 kDa and 5 MDa, or AAV empty/partial/full ratios, requiring minimal sample and minimal sample prep for analysis. In this talk, we demonstrate the utility of the TwoMP as a tool to measure critical quality attributes of your samples, or to quickly, easily monitor antibody-antigen interactions, quantify small-molecule induced changes to complex formation, assess sample purity and more.  We wil also discuss capabilities of the SamuxMP in characterizing AAV samples. We will show that it can differentiate between empty, partially filled and full AAV capsids, and that is serotype agnostic. The SamuxMP measurements are in line with gold-standard techniques such as TEM and AUC.

Unearth the real value of your complex biopharma analytical data through a powerful enterprise software platform

Jan 26, 2023 12:30pm ‐ Jan 26, 2023 1:30pm

As biopharmaceuticals are becoming increasingly complex, the data generated with different analytical techniques is increasing in volume and variety. Obtaining the prescient insights scientists need and can subsequently be fed into further stages of development has been hindered by the fact that data come from all over the place and is disconnected. Worse, results are often locked into desktop software and sharing reports is manual and cumbersome. Instead, with Deep Query tools from Protein Metrics, and Dashboards for visualising data mining, you get instant access, with shareable insight.

Mass spectrometry data produces extremely valuable data for biotherapeutic research, development and production. Advanced enterprise data systems allow organizations to curate, interrogate and faithfully share that information for timely decision-making. As many companies are embracing digital transformation, researchers are not only looking for solutions that allow easier data sharing by leveraging cloud capabilities, but are looking for platforms that offer data processing in a native web environment, which are accessible from anywhere, so that scientists are no longer bound to their desktop software or manual information sharing.  

In this short presentation, you can learn about advancements in ByosphereA, Protein Metrics' vendor neutral enterprise software platform: Enable your organization's scientists to process data easily in front of any computers with web access from anywhere and share the results just as easily with colleagues with access to the same data. Make your data work for you in an effortless and automated fashion by turning it into actionable insights only within minutes after an acquisition is completed. Analytical scientists will never want to go back to old ways if they discover how data mining with deep query and visualization of the processed and extracted information with dynamic dashboards can enable them to do their work faster with insights at a glance. 

Get the value out of your complex data by processing it faster, sharing it easily, and summarizing it for non-experts in a GxP environment.