Characterization of Adeno-Associated Viruses and Lipid Nanoparticles - Technical Seminar Sponsored by SCIEX

In-depth characterization of Adeno-Associated Virus (AAV) is important for quality assurance and safety of AAV products in gene therapy industry. Capillary Electrophoresis (CE) is a technology which could provide fast, reliable and robust analysis of AAV capsid protein purity with high sensitivity, AAV full and empty ratio determination, AAV charge variants and integrity analysis of genome packaged in AAV capsids which are critical workflows for AAV product analysis. Additionally, advancements in pharmaceutical development have led to novel ways in which therapeutics are delivered. Emerging drug delivery mechanisms are liposomes, currently being utilized as therapeutic transport systems. The expansion of liposomes to more specialized lipid nanoparticles (LNPs) has further developed this area of therapeutics and LC-MS has emerged as a robust technique for their profiling and quantification.