Keynote Session I: Quantitative Proteomics for Understanding Histone Mutations in Human Disease iconKeynote Session I: Quantitative Proteomics for Understanding Histone Mutations in Human Disease

Keynote Session I: Quantitative Proteomics for Understanding Histone Mutations in Human Disease

Sep 6, 2023 9:00am ‐ Sep 6, 2023 10:00am

Identification: 73544




Quantitative Proteomics for Understanding Histone Mutations in Human Disease (45 minutes)

Q&A (15 minutes)




Session Speaker: Benjamin Garcia, Washington University in St. Louis

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Keynote Presentation
Session I: Molecular Design, Developability and Biotransformation iconSession I: Molecular Design, Developability and Biotransformation

Session I: Molecular Design, Developability and Biotransformation

Sep 6, 2023 10:15am ‐ Sep 6, 2023 11:50am

Identification: 73547

Session Speakers:




Importance of Disulfide Bond re-arrangement in vitro and in vivo: Evidence and Approaches to Address It
Franta Hubálek, Novo Nordisk A/S




Development of a Rapid and Automated, Compliance Ready Workflow for Full Sequence Coverage of RNAi Therapeutics
Jennifer Nguyen, Alnylam Pharmaceuticals




Elucidation, Characterization and Monitoring of a Unique Tyrosine Sulfation Post-Translational Modification During Bispecific Antibody Process Development and Scaleup
David Mahon, Bristol-Myers Squibb Company

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Technical Seminar: Presented by GenNext Technologies, Inc. iconTechnical Seminar: Presented by GenNext Technologies, Inc.

Technical Seminar: Presented by GenNext Technologies, Inc.

Sep 6, 2023 12:30pm ‐ Sep 6, 2023 1:00pm

Identification: 73550




Technical Seminar Lunch & Learn Sessions are for Mass Spec attendees only. HOS attendees and those not wishing to attend should grab their lunch and proceed to the Explore Room (Floor 2).

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Featured Joint Keynote Presentation: Hacking Structural Biology for Drug Delivery Using Protein Footprinting Based Mass Spectrometry iconFeatured Joint Keynote Presentation: Hacking Structural Biology for Drug Delivery Using Protein Footprinting Based Mass Spectrometry

Featured Joint Keynote Presentation: Hacking Structural Biology for Drug Delivery Using Protein Footprinting Based Mass Spectrometry

Sep 6, 2023 1:55pm ‐ Sep 6, 2023 2:45pm

Identification: 73552

Joint Keynote Presenter Mark R. Chance Has a Message for You

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Keynote Presentation
Session II: Emerging Mass Spectrometry Technologies for HOS iconSession II: Emerging Mass Spectrometry Technologies for HOS

Session II: Emerging Mass Spectrometry Technologies for HOS

Sep 6, 2023 3:30pm ‐ Sep 6, 2023 6:00pm

Identification: 73555

Session Speakers:




High-Order Structure Characterization of Membrane Proteins Using Benzoyl Fluoride Footprinting
Mengqi Chai, Washington University in St. Louis  

  

In Depth Characterization of Biologics Through a Combination of Mass Spectrometry and Molecular Modeling
Naresh Chennamsetty, Bristol-Myers Squibb Company




Protein Footprinting for Structural Biology in Complex Model Systems
Lisa Jones, University of California San Diego    




Complementary Backbone and Side Chain Analysis of Drug – Protein Interactions Combining Hydrogen/Deuterium Exchange and Protein Oxidative Mass Spectrometry
Yan Sun, Albert Einstein College of Medicine    

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Keynote Session III: Mass Spectrometry Enables More Definitive Process & Product Development Towards Well-Characterized Biotherapeutics: A Personal Account iconKeynote Session III: Mass Spectrometry Enables More Definitive Process & Product Development Towards Well-Characterized Biotherapeutics: A Personal Account

Keynote Session III: Mass Spectrometry Enables More Definitive Process & Product Development Towards Well-Characterized Biotherapeutics: A Personal Account

Sep 7, 2023 8:50am ‐ Sep 7, 2023 9:50am

Identification: 73562

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Mass Spectrometry Enables More Definitive Process & Product Development Towards Well-Characterized Biotherapeutics: A Personal Account
Jason Rouse, Pfizer, Inc.


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Session III: Mass Spectrometry in Gene and Cell Therapy iconSession III: Mass Spectrometry in Gene and Cell Therapy

Session III: Mass Spectrometry in Gene and Cell Therapy

Sep 7, 2023 10:20am ‐ Sep 7, 2023 11:55am

Identification: 73565

Session Speakers:




Applications of Mass Spectrometry in CRISPR based Cell Therapy and Gene Editing Therapy
Bo Yan, Beam Therapeutics    




LC-MS/MS as a Potency Assay for mRNA Vaccines
Aline Dörrbaum, BioNTech SE    




Proteomic Approaches for Characterization of Live Biotherapeutic Escherichia coli Nissle Products from Fermentation to Therapeutic Activity
Steven Bruckbauer, Synlogic Operating Company

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Mass Spec 20th Anniversary Vendor Showcase ~ Presented by Waters Corporation iconMass Spec 20th Anniversary Vendor Showcase ~ Presented by Waters Corporation

Mass Spec 20th Anniversary Vendor Showcase ~ Presented by Waters Corporation

Sep 7, 2023 12:05pm ‐ Sep 7, 2023 12:35pm

Identification: 73567







Mass Spec attendees should grab their lunch and beverages and return to the general session room if they plan on attending the vendor showcase. 

*The vendor showcases are not part of the HOS Symposium.

Mass Spec 20th Anniversary Vendor Showcase ~ Presented by MOBILion Systems, Inc. iconMass Spec 20th Anniversary Vendor Showcase ~ Presented by MOBILion Systems, Inc.

Mass Spec 20th Anniversary Vendor Showcase ~ Presented by MOBILion Systems, Inc.

Sep 7, 2023 12:35pm ‐ Sep 7, 2023 1:05pm

Identification: 73568







HOS attendees should grab their lunch and proceed to the meal room to eat. 

The Regulator Panel: Can We Talk? iconThe Regulator Panel: Can We Talk?

The Regulator Panel: Can We Talk?

Sep 7, 2023 2:05pm ‐ Sep 7, 2023 2:55pm

Identification: 73569

Featured Panelists:




Wayne Hicks, CBER, FDA  

Frances Namuswe, CDER, FDA  

Sarah Rogstad, CDER, FDA