Keynote Session I: Quantitative Proteomics for Understanding Histone Mutations in Human Disease

Sep 6, 2023 9:00am ‐ Sep 6, 2023 10:00am

Identification: 73544




Quantitative Proteomics for Understanding Histone Mutations in Human Disease (45 minutes)

Q&A (15 minutes)




Session Speaker: Benjamin Garcia, Washington University in St. Louis

Session I: Molecular Design, Developability and Biotransformation

Sep 6, 2023 10:15am ‐ Sep 6, 2023 11:50am

Identification: 73547

Session Speakers:




Importance of Disulfide Bond re-arrangement in vitro and in vivo: Evidence and Approaches to Address It
Franta Hubálek, Novo Nordisk A/S




Development of a Rapid and Automated, Compliance Ready Workflow for Full Sequence Coverage of RNAi Therapeutics
Jennifer Nguyen, Alnylam Pharmaceuticals




Elucidation, Characterization and Monitoring of a Unique Tyrosine Sulfation Post-Translational Modification During Bispecific Antibody Process Development and Scaleup
David Mahon, Bristol-Myers Squibb Company

Technical Seminar: Presented by GenNext Technologies, Inc.

Sep 6, 2023 12:30pm ‐ Sep 6, 2023 1:00pm

Identification: 73550




Technical Seminar Lunch & Learn Sessions are for Mass Spec attendees only. HOS attendees and those not wishing to attend should grab their lunch and proceed to the Explore Room (Floor 2).

Featured Joint Keynote Presentation: Hacking Structural Biology for Drug Delivery Using Protein Footprinting Based Mass Spectrometry

Sep 6, 2023 1:55pm ‐ Sep 6, 2023 2:45pm

Identification: 73552


Session II: Emerging Mass Spectrometry Technologies for HOS

Sep 6, 2023 3:30pm ‐ Sep 6, 2023 6:00pm

Identification: 73555

Session Speakers:




High-Order Structure Characterization of Membrane Proteins Using Benzoyl Fluoride Footprinting
Mengqi Chai, Washington University in St. Louis  

  

In Depth Characterization of Biologics Through a Combination of Mass Spectrometry and Molecular Modeling
Naresh Chennamsetty, Bristol-Myers Squibb Company




Protein Footprinting for Structural Biology in Complex Model Systems
Lisa Jones, University of California San Diego    




Complementary Backbone and Side Chain Analysis of Drug – Protein Interactions Combining Hydrogen/Deuterium Exchange and Protein Oxidative Mass Spectrometry
Yan Sun, Albert Einstein College of Medicine    

Keynote Session III: Mass Spectrometry Enables More Definitive Process & Product Development Towards Well-Characterized Biotherapeutics: A Personal Account

Sep 7, 2023 8:50am ‐ Sep 7, 2023 9:50am

Identification: 73562

Session Speaker:




Mass Spectrometry Enables More Definitive Process & Product Development Towards Well-Characterized Biotherapeutics: A Personal Account
Jason Rouse, Pfizer, Inc.



Session III: Mass Spectrometry in Gene and Cell Therapy

Sep 7, 2023 10:20am ‐ Sep 7, 2023 11:55am

Identification: 73565

Session Speakers:




Applications of Mass Spectrometry in CRISPR based Cell Therapy and Gene Editing Therapy
Bo Yan, Beam Therapeutics    




LC-MS/MS as a Potency Assay for mRNA Vaccines
Aline Dörrbaum, BioNTech SE    




Proteomic Approaches for Characterization of Live Biotherapeutic Escherichia coli Nissle Products from Fermentation to Therapeutic Activity
Steven Bruckbauer, Synlogic Operating Company

Mass Spec 20th Anniversary Vendor Showcase ~ Presented by Waters Corporation

Sep 7, 2023 12:05pm ‐ Sep 7, 2023 12:35pm

Identification: 73567







Mass Spec attendees should grab their lunch and beverages and return to the general session room if they plan on attending the vendor showcase. 

*The vendor showcases are not part of the HOS Symposium.

Mass Spec 20th Anniversary Vendor Showcase ~ Presented by MOBILion Systems, Inc.

Sep 7, 2023 12:35pm ‐ Sep 7, 2023 1:05pm

Identification: 73568







HOS attendees should grab their lunch and proceed to the meal room to eat. 

The Regulator Panel: Can We Talk?

Sep 7, 2023 2:05pm ‐ Sep 7, 2023 2:55pm

Identification: 73569

Featured Panelists:




Wayne Hicks, CBER, FDA  

Frances Namuswe, CDER, FDA  

Sarah Rogstad, CDER, FDA