Tsega obtained her BSc (Chemistry) and PhD (Biochemistry) from the University of Virginia (USA) and University of Maryland (USA), respectively. Her PhD dissertation was regarded as a ground-breaking work in understanding how protein shape switching works by investigating the mechanisms by which proteins switch three-dimensional structures in response to cellular environment. She worked on the design and characterization of a protein mechanosensors during her postdoctoral fellowship at the National Institute of Health (NIH). Tsega is currently working at the National Institute of Standards and Technology (NIST, USA), where she received the National Research Council (NRC) postdoctoral fellowship to continue her research as a protein chemist. Her research at NIST centers around the application of high-resolution NMR spectroscopy methods for higher order structural analysis of therapeutic monoclonal antibodies.